STOX1 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA765089LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STOX1 Polyclonal antibody

Uniprot No.

Q6ZVD7

Target Names

STOX1

Alternative Names

STOX1 antibody; C10orf24 antibody; Storkhead-box protein 1 antibody; Winged-helix domain-containing protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Storkhead-box protein 1 protein (559-858AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway.; Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.

Gene References into Functions

The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath. PMID: 26758611
Transcription factor STOX1A and its target gene, CNTNAP2, are potentially involved in the etiology of Alzheimer's disease. PMID: 22728895
STOX1 is one of the genes that give susceptibility for preeclampsia. PMID: 21490791
A STOX1A-dependent effect on tau phosphorylation found in neurodegenerative diseases such as Alzheimer's disease. PMID: 22995177
Mitotic entry is enhanced through the direct upregulation of cyclin B1 expression effectuated by STOX1A. PMID: 22253775
Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration. PMID: 21755018
STOX1 does not show differential expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls. PMID: 20643876
methylation is independent of parental origin, but regulates STOX1 expression with the Y153H genotype directing the level of methylation. PMID: 20716964
The risk allele (Y153H) of the preeclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein a-T-catenin (CTNNA3). PMID: 20400461
role in placental development and preeclampsia (Review) PMID: 19577309
The data of this study indicated that STOX1 controls a conserved pathway shared between placenta and brain with overexpression in late-onset Alzheimer's disease. PMID: 20110611
In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene. PMID: 17290274
Anomalies in STOX1 expression are associated with the onset of preeclampsia. PMID: 19079545

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Involvement in disease

Pre-eclampsia/eclampsia 4 (PEE4)

Subcellular Location

[Isoform A]: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform B]: Nucleus.; [Isoform C]: Nucleus, nucleolus.

Tissue Specificity

Expressed in placenta, including the invasive extravillus trophoblast cells.

Database Links

HGNC: 23508

OMIM: 609397

KEGG: hsa:219736

STRING: 9606.ENSP00000298596

UniGene: Hs.37636

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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